The patient began treatment with oral carvedilol 3.125mg in order to assess bet narrowing of the aortic heart valve. Dobutamine/arbutamine (applies to Part of dobutamines action is on beta 1 and beta 2 receptors and therefore concomitant beta-blocker therapy can be expected to blunt a patients hemodynamic response to dobutamine. dobutamine (doe-byoo-ta-meen) Dobutrex. Dobutamine Price of 37 Brands. Dobutamine, especially when administered in high doses, can result in a sharp blood pressure increase and cardiac arrhythmia. This is the result of "intelligent drug design". Classification. Cleveland Clinic is a non-profit academic medical center. It is used to treat congestive heart failure. Find information on Dobutamine (Dobutrex) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Cipro have. Dobutamine drug interactions. As well as a well-defined catechol group, it possesses a humongous amine substituent group, which confer upon it a high level of beta-1 selectivity. Halogenated anesthetics potentiate the positive inotropic effects of alpha- and beta-adrenoceptor stimulations, but their interactions with dobutamine remain unknown.Methods. 4.5 Interaction with other medicinal products and other forms of interaction. Dobutamine is predicted to increase the risk of a hypertensive crisis when given with Phenelzine. Major Potential Hazard, Moderate plausibility. Effect of interaction is not clear, use aceclofenac aceclofenac increases and dobutamine decreases serum potassium. 5 mg/mL if fluid restricted) with Glucose 5% or Sodium Dose range of 0.5-40 mcg/kg/min may be given. Common interactions include laceration among females and anhedonia among males. Find patient medical information for Dobutamine Hcl W/Dextrose intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. We also discuss the various positive inotrope regimens (phosphodiesterase inhibitors, levosimendan, dobutamine) and their interactions with beta blockers in decompensated HF. Use Caution/Monitor. Dobutamine Hydrochloride is indicated when inotropic support is necessary for the treatment of patients with hypoperfusion states in whom cardiac output is insufficient to meet circulatory demands. Davis Drug Guide PDF. Use Caution/Monitor. Dobutamine directly stimulates beta-1 receptors of the heart to increase myocardial contractility and stroke volume, resulting in increased cardiac output. Interactions. Drug interactions secondary to inhibition of the CYP 450 enzyme system are likely the most well known of all drug interactions, and they occur more frequently than enzyme induction. Therapeutic: inotropics. Background. Interaction more likely in certain predisposed pts. dobutamine. Find information on Dobutamine (Dobutrex) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge It is commercially available as a 50:50 Manufacturer advises dobutamine injection should be diluted before use or given undiluted with syringe pump. The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Definity have. Find patient medical information for dobutamine intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions. It helps increase the strength of the heart muscle. Via competitive receptor inhibition, the sympathomimetic effect of dobutamine can be reduced by simultaneous administration of a beta receptor blocker. Adult: 2.5-10 mcg/kg/min. Medications known to have contraindicated interactions with dobutamine iv. Drug Interactions Animal studies indicate that dobutamine may be ineffective if the patient has recently received a -blocking drug. Dobutamine. The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Tacrolimus have. Use WebMDs Drug Interaction Checker tool to find and identify potentially harmful and unsafe combinations of prescription medications by entering two or more drugs in question. In Pharmacologic: adrenergics + + + Indications + + Short-term (<48 hr) management of heart failure caused by depressed contractility from organic heart butalbital-aspirin-caffeine oral and dobutamine iv butalbital-aspirin-caffeine oral increases and dobutamine iv decreases sedation and drowsiness. Patient Drug Interactions Source: RxList Heart failure is a multifactorial condition that affects roughly 1-2% of the adult population. Dobutamine used in clinical practice is a racemic mixture of (+) and () enantiomers ().The ()-enantiomer exerts a potent pressor activity mediated by alpha-1 stimulation and also produces marked increases in cardiac output, stroke volume, total peripheral resistance and mean arterial pressure, but does not induce significant increases in heart rate (). Tell your doctor all medications and supplements you use. Dobutamine in 5% Dextrose Injection, USP is a sterile, nonpyrogenic, prediluted solution of dobutamine hydrochloride and dextrose in water for injection. Price List Updated on February, 2, 2017. Dobutamine concentrate for intravenous infusion should be diluted before use.. For intravenous infusion, manufacturer advises give continuously in Glucose 5% or Sodium chloride 0.9%.Dilute to a concentration of 0.51 mg/mL and give via an infusion pump; give higher It is a syn- Drug Interactions Animal studies indicate that dobutamine may be ineffective if the patient has recently received a -blocking drug. The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Diprivan have. Dobutamine hydrochloride may cause a marked increase in heart rate or blood pressure, especially systolic pressure. Adjust according to patient's BP, heart rate, cardiac and urine output. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. Dobutamine Interaction with 147 drugs. This is the result of "intelligent drug design". You can use the study as a second opinion to make health care decisions. Other Beta-blockers. No age-related differences were noted in the responses of plasma insulin, glucose, fatty acid, or lactate levels to dobutamine. It stimulates the heart muscle. ozanimod increases toxicity of milrinone by sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Part of dobutamines action is on beta 1 and beta 2 receptors and therefore concomitant beta-blocker therapy can be expected to blunt a patients hemodynamic response to dobutamine. It is created by eHealthMe based on reports of 19 people who take Dobutamine hydrochloride and Diprivan from the FDA, and is updated regularly. Dobutamine (applies to dobutamine) asthmatics. It is created by eHealthMe based on reports of 1 person who takes the same drugs from the FDA, and is updated regularly. Dobutamine can induce vasoconstriction and a sharp increase in blood pressure when used in combination with -adrenoceptor blockers. List of interactions for Dobutamine. I.V. The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Olmetec have. For continuous intravenous infusion, manufacturer advises using infusion pump, dilute to a concentration of 0.51 mg/mL (max. Interactions for DOBUTamine No evidence of interactions in clinical studies when used with atropine, cardiac glycosides (digoxin), furosemide, heparin, lidocaine, morphine, nitroglycerin, isosorbide dinitrate, potassium chloride, folic acid, protamine, acetaminophen, or spironolactone. Drug Interactions: There was no evidence of drug interactions in clinical studies in which dobutamine hydrochloride was administered concurrently with other drugs, including digitalis preparations, furosemide, spironolactone, lidocaine, glyceryl trinitrate, isosorbide dinitrate, Dobutamine is an inotropic agent useful in the treatment of decompensated heart failure. high blood pressure. It is unknown if dobutamine passes into breast Digoxin and dobutamine belong to different drug classes. Load more Dobutamine Interacts with Diseases Interaction References; Dobutamine results in increased expression of HMOX1 mRNA: R: Close Interactions list Interactions list. It is created by eHealthMe based on reports of 1 person who takes the same drugs from the FDA, and is updated regularly. Dobutamine has moderate interactions with at least 256 different drugs. Find out more in the list below: 3-Iodobenzylguanidine The therapeutic efficacy of Iobenguane can be decreased when used in Common interactions include renal failure among females and anaemia among males. All generic drug interactions for dobutamine iv (lists will include brand and generic names): 18 serious drug interactions. Dobutamine stimulates heart muscle and improves blood flow by helping the heart pump better. Dobutamine is used short-term to treat cardiac decompensation due to weakened heart muscle. Dobutamine is usually given after other heart medicines have been tried without success. Find out more about BNF interactions information. Alpha-blockers. Dobutamine can rarely reduce the potassium concentrations to hypokalemic levels. Therapeutic: inotropics. DOBUTAMINE (DOE byoo tah meen) is an inotrope. Indications and Dosage. Clinically, dobutamine increases cardiac output by selectively augmenting stroke volume, and this is associated with a decrease in total peripheral vascular resistance that is mediated, in part, by reflex withdrawal of sympathetic tone to the vasculature. Dobutamine may interact with beta-blockers and nitroprusside. Milrinone is a PDE-III inhibitor with inotropic, lusitropic, and vasodilatory properties used for the short-term treatment of acute decompensated heart failure.. Generic Name Milrinone DrugBank Accession Number DB00235 Background. Why does dobutamine cause hypotension? We propose that the drop in blood pressure with dobutamine in this patient was caused by a fall in systemic vascular resistance due to vascular beta2-adrenergic receptor activation. The normal increase in cardiac output was partially blocked by selective beta1-adrenergic blockade at low doses of carvedilol. DRUG INTERACTIONS. Side effects of digoxin and dobutamine that are similar include nausea and headache. Does dobutamine intravenous interact with other medications? The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Lithium carbonate have. Dobutamine is an inotropic agent useful in the treatment of decompensated heart failure. Severe interactions are highlighted with a red marker. Known drug interactions. dobutamine (doe-byoo-ta-meen) Dobutrex. Find information on Dobutamine (Dobutrex) in Daviss Drug Guide including dosage, side effects, interactions, nursing implications, mechanism of action, half life, administration, and more. Dobutamine administration may produce symptomatic benefits in patients with acute decompensated heart failure, however, routine use of intermittent inotropic infusions has been shown to increase mortality in patients with chronic heart failure. As well as a well-defined catechol group, it possesses a humongous amine substituent group, which confer upon it a high level of beta-1 selectivity. Manufacturer advises avoid and for 14 days after stopping the MAOI. In such a case, the peripheral vascular resistance may increase. This strategy may increase adherence to beta blockers after discharge and lower rehospitalization and mortality rates. Serious side effects have been reported with dobutamine including significant changes in heart rate or blood pressure and allergic reactions. The effects of dopamine, (+/-)-dobutamine (racemic mixture) and (-)-dobutamine on alpha-adrenoceptor-mediated vasoconstriction were evaluated in the pulmonary circulation of the anesthetized dog. The following adverse effects have been reported in 1% to 3% of patients: nausea, headache, anginal pain, nonspecific chest pain, palpitations, and shortness of breath. Dobutamine injection (Dobutrex brand is no longer available in the US) is a prescription heart disease drug. Tell your healthcare provider right away if you have some or all of the following symptoms: irregular heartbeat. Child: Neonates to 18 yr Initially, 5 mcg/kg/min, adjust to 2-20 mcg/kg/min according to response. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. dobutamine and dopamine both decrease sedation. Because the active metabolite of ozanimod inhibits MAO-B in vitro, there is a potential for serious adverse reactions, including hypertensive crisis. These medications may cause some risk when taken together. Drug interactions are reported only by a few people who take Dobutamine hydrochloride and Olmetec together. COMMON BRAND NAME (S): Dobutrex. Dobutamine contains sulfite, which can lead to reactions in rare patients with sulfite hypersensitivity. It is created by eHealthMe based on reports of 9 people who take Dobutamine hydrochloride and Cipro from the FDA, and is updated regularly. hypertrophic cardiomyopathy. It is created by eHealthMe based on reports of 1 person who takes the same drugs from the FDA, and is updated regularly. Drug interactions are reported only by a few people who take Dobutamine hydrochloride and Definity together. Drug Interactions Animal studies indicate that dobutamine may be ineffective if the patient has recently received a -blocking drug. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY. a heart attack. Davis Drug Guide PDF. Side effects of digoxin that are different from dobutamine include vomiting, diarrhea, dizziness, skin rash, and mental changes. Drug Interactions: 1) Beta blocking agents will inhibit the cardiovascular effects of dobutamine; 2) MAO inhibitors and tricyclic antidepressants may enhance the pressor effect of dobutamine. drug interactions, recommended dosages, and pregnancy and breastfeeding safety information are provided. Drug interactions are reported only by a few people who take Dobutamine hydrochloride and Definity together. Absorption Not Available Volume of distribution Not Available Protein binding Not Available Metabolism Not Available Route of elimination Drug Interactions Animal studies indicate that dobutamine may be ineffective if the patient has recently received a -blocking drug. Preliminary studies indicate that the concomitant use of dobutamine and nitroprusside results in a higher cardiac output and, usually, a lower pulmonary wedge pressure than when Notes for Professionals: Caffeine is a CNS-stimulant and such actions are expected to be additive when coadministered with other CNS stimulants or psychostimulants. Interactions. Dobutamine interaction Dobutamine interaction 2013-01-17 00:00:00 Reactions 789 - 19 Feb 2000 Interaction with concomitant carvedilol leading to hypotension: case report A 54-year-old man with severe heart failure developed hypotension after he received treatment with dobutamine in addition to carvedilol. Acebutolol. Dobutamine hydrochloride is a direct-acting inotropic agent whose primary activity results from stimulation of the receptors of the heart while producing comparatively mild chronotropic, hypertensive, arrhythmogenic, and vasodilative effects. Anesthetics (Drugs that block sensation), such as: Lidocaine. Dobutamine During Pregnancy and Breastfeeding Dobutamine should be used during pregnancy only if clearly needed. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Davis Drug Guide PDF. What are the side effects of dobutamine?fever,headache,nausea, andshortness of breath. more likely w/thioridazine than other phenothiazines. Dobutamine concentrate for intravenous infusion should be diluted before use.. For continuous intravenous infusion, manufacturer advises using infusion pump, dilute to a concentration of 0.51 mg/mL (max. Dobutamine Disease Interactions. Dobutamine Injection, USP is a clear, practically colorless, sterile, nonpyrogenic solution of dobutamine hydrochloride for intravenous use only. Mild interactions of dobutamine include: bendroflumethiazide bumetanide chlorothiazide chlorthalidone cyclopenthiazide desmopressin ethacrynic acid eucalyptus furosemide hydrochlorothiazide indapamide methyclothiazide metolazone noni juice sage torsemide Digoxin is a cardiac glycoside and dobutamine is a synthetic catecholamine. DOBUTamine Injection USP Rx ONLY DESCRIPTION Dobutamine Injection USP is ()-4-[2-[[3-(p-Hydroxyphenyl)-1-methylpropyl]amino]ethyl]-pyrocatechol hydrochloride. Dose : 2-8 g /kg/min. It is created by eHealthMe based on reports of 2 people who take the same drugs from the FDA, and is updated regularly. Top Gene Interactions. Monitor Closely (243) acebutolol acebutolol increases and dobutamine decreases serum potassium. Identification Summary. Moderate Interactions. flurazepam increases and isoproterenol decreases sedation. Adult: 5 mcg/kg/min for 8 min via infusion pump using a soln containing 1 mg/mL. chest pain. Dobutamine is a synthetic catecholamine. Interaction more likely in certain predisposed pts. Does dobutamine intravenous interact with other medications? With dobutamine infusion, MFAU and MFAO increased by a similar extent in both younger and older volunteers (age/dobutamine flurazepam. Includes DOBUTamine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Avoid or Use Alternate Drug. Other rare adverse effects have occurred in one to three percent of the patients, including nausea, headaches, chest pain, palpitations, and shortness of breath. In such a case, the peripheral vascular resistance may increase. dobutamine and dopamine both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. Manufacturer advises dobutamine injection should be diluted before use or given undiluted with syringe pump. Dobutamine concentrate for intravenous infusion should be diluted before use. atrial fibrillation. The drugs were studied in the absence and presence of propranolol (1 mg/kg, i.v.) Dobutamine : Therapeutic uses, Dosage & Side Effects Dobutamine (cathecholamine) is a adrenergic agonist (direct acting), used as Cardiac stimulants in treating heart failure caused by surgery or heart disease. Dobutamine Injection, USP is a clear, practically colorless, sterile, nonpyrogenic solution of dobutamine hydrochloride for intravenous use only. There are 5 disease interactions with dobutamine which include: asthmatics; arrhythmias; hypotension; IHSS; hypokalemia Specific Drugs Dobutamine drug interactions (more detail) Serious - Use Alternative (2) ozanimod. Dobutamine concentrate for intravenous infusion should be diluted before use.. For intravenous infusion, manufacturer advises give continuously in Glucose 5% or Sodium chloride 0.9%.Dilute to a concentration of 0.51 mg/mL and give via an infusion pump; give higher Dopamine and dobutamine are often infused together into acutely ill patients requiring temporary support of cardiac and renal function, but whether these catecholamines affect the metabolic clearance of each other is not established. 27 interactions . What Drugs, Substances, or Supplements Interact with Dobutamine? The effects of halothane, isoflurane, sevoflurane, and desflurane (1 and 2 minimum alveolar concentration) on the inotropic responses induced by dobutamine (10(-8)-10(-4) M) were Common side effects of dobutamine may include: nausea, vomiting; fever, tingly feeling; headache; or leg cramps. dobutamine CLINICAL USE Inotropic agent DOSE IN NORMAL RENAL FUNCTION 2.510 micrograms/kg/minute, increasing up to 40 micrograms/kg/minute according to response PHARMACOKINETICS ; Molecular weight :301.4; 337.8 (as hydrochloride) %Protein binding :No data %Excreted unchanged in urine : dobutamine and isoproterenol both decrease serum potassium. Drug Interactions Animal studies indicate that dobutamine may be ineffective if the patient has recently received a -blocking drug. low amount of potassium in the blood. Classification. Includes DOBUTamine indications, dosage/administration, pharmacology, mechanism/onset/duration of action, half-life, dosage forms, interactions, warnings, adverse reactions, off-label uses and more. Pharmacologic: adrenergics + + + Indications + + Short-term (<48 hr) management of heart failure caused by depressed contractility from organic heart 431 significant drug Related Pathways. Brand Names Include: Dobutrex IV. dobutamine. Dobutamine is a synthetic catecholamine. Manufacturer advises dobutamine injection should be diluted before use or given undiluted with syringe pump. Find patient medical information for Dobutamine Hcl W/Dextrose intravenous on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. infusion (MUST BE DILUTED PRIOR Drugs that can cause dangerous interactions with this medication include: Blood pressure drugs, such as: Angiotensin-Converting Enzyme (ACE) Inhibitors. Other drugs may interact with dobutamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Learn Find everything you need to know about Dobutamine (Dobutrex), including what it is used for, warnings, reviews, side effects, and interactions. Dobutamine is a commonly used positive inotrope for the short-term management of heart failure. All generic drug interactions for dobutamine iv (lists will include brand and generic names): 5 contraindicated drug interactions 18 serious drug interactions 431 significant drug interactions 51 minor drug interactions Patients and Caregivers Clinician Explanation Monitor Closely Potential for interaction digoxin oral and dobutamine iv The phase IV clinical study analyzes what interactions people who take Dobutamine hydrochloride and Definity have. Dobutamine(Dobutrex) generic is a sympathomimetic compound used in the treatment of heart failure and cardiogenic shock. Side effects include shortness of breath, nausea, fever, headache, and increased blood pressure. Dobutamine Hydrochloride in 5% Dextrose Injection is a sterile, nonpyrogenic solution of Dobutamine Hydrochloride, USP and Dextrose, USP in Water for Injection, USP. Risk of cardiac arrhythmia or sudden death, more likely w/thioridazine than other phenothiazines. only. Dobutamine has the following interaction information: Drug interaction information. Dobutamine disease interactions. Dobutamine 5 mg/ml (250 mg in 50 ml) ampoule or vial. It may also be used for other conditions as determined by your doctor. Start studying Dobutamine. Dobutamine injection contains sodium metabisulfite, a Dobutamine/arbutamine (applies to dobutamine) arrhythmias. It is created by eHealthMe based on reports of 13 people who take Dobutamine hydrochloride and Tacrolimus from the FDA, and is updated regularly. increases in blood pressure and heart rate. There are 156 drug interactions with dobutamine.